#Nanopore #protein #sequencing comes closer! Show more
In this week's issue of #PNAS, van Ginkel, ..., and Joo, from the Kavli Institute of Nanoscience, Delft University of Technology, Netherlands, demonstrate the use of FRET (energy transfer between fluorescent molecules that are very close each other) to detect key residues of a peptide passing through a pore (related to the AAA+ protease ClpXP from E. coli). https://doi.org/10.1073/pnas.1707207115
#Ultimaker printers are tested before being shipped. When preparing for the first print, we saw a drop of plastic extruded from the print core, so we thought that we did it right. But it was only leftovers from the maker's test. Actually, we had completely misunderstood the instructions, and did not even insert the material filament in the bowden tube! Now problem solved! Thanks fbrc8's video for opening our eyes. https://www.youtube.com/watch?v=uPWlZw8cTpc
Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells. Show more
Noticing that the gene causing Huntington's disease was also reducing the frequency of some cancers, Murmann, ..., and Peter (Northwestern University, Chicago) found that small RNAs containing the pathogenic sequences (triplet repeats) from the gene were toxic to cancer cells. These RNAs can be synthesized and therefore might become a new tool for medecine.
"Data notes" in "BMC Research Notes": a manuscript format sharing similar goals with the "Data descriptors" of "Scientific data".
The IMS applies interdisciplinary approaches which includes genome-wide medical science, immunology and physiology, bioinformatics, and molecular, biochemical and quantitative sciences.
Applicants must be distinguished international students in a Master's or Ph.D. course or young postdocs who received their Ph.D. within the last three years.
Open data has a source; this week's Policy Forum in Science reminds to respect it:
“researchers using open data should strive to conduct ethical studies relevant to local communities and return results to them”
Long version Show more
Hans Jonatan, born in the Caribbean in the 18th century to an enslaved African mother and European father, migrated to Iceland and founded a family there.
In the 21st century, researchers from Iceland studied the genes of 788 of his descendants (including whole-genome sequencing for 20 of them), and reconstructed 38% of his mother's genome. The data suggests that his mother was from the region spanned by Benin, Nigeria and Cameroon.
Rephrased from https://doi.org/10.1038/s41588-017-0031-6
All interested in participating can apply till The, Feb 1st, 2018.
RIKEN CLST will be able to fund part of the travel costs for a limited number of students from Japanese Universities.
For more details and the registration page please consult the below link.
I will teach about #reproducible research at the course "Bioinformatics analysis of gene regulation in omics data and its applications to medical problems" organised by the #Karolinska Institute (#KI Course number 3027) and #RIKEN. The course will take place in #Stockholm from March 5 to March 9. Course websites: <http://clst.riken.jp/en/topics/event/170305event/>, <http://kiwas.ki.se/katalog/katalog/kurs/2693>.
Perhaps we should supplement the singular and plural forms with a dual form (https://en.wikipedia.org/wiki/Dual_(grammatical_number)) in scientific litterature to make it clearer when "multiple" means "only two".
Extracting factual information from abstracts of high-impact journals is a cognitive challenge. For instance, beginners may not pay attention that claims such as "in diverse cell types" may only mean "in the two cell types that we tested". This reminds me a bit the patent jargon...
New #amphiphilic surfactants containing gold, iron oxide or lead sulfide were used to create droplets that aggregate in magnetic fields, translate or rotate under laser illumination, and weld together electric fields. Published in #Nature. https://doi.org/10.1038/nature25137
A study published in #Nature by Collins, ..., and Britton, from the Baylor College of Medicine, suggests that a subpopulation of gut bacteria adapted to the presence of #trehalose in our intestines, where it can be found in larger amounts since 2000/2001 when this additive was approved in the US and the EU. Article: https://doi.org/10.1038/nature25178 Free summary: https://www.nature.com/articles/d41586-017-08775-4
Cells induced to differentiate and colonise a target organ: In this week's issue of #PNAS, by Han, ..., and Lerner from The Scripps, who found a single synthethic gene sending cells to the brain.
In brief: a library of single-chain antibodies was transfected in bone-marrow cells, which were translanted in mice. The cells that migrated in the brain were enriched for a synthethic gene expresing an #antibody that binds Vimentin and causes it to be phosphorylated. https://doi.org/10.1073/pnas.1719259115
In the R language, given tables in matrix, data.frame or data.table classe, I did not find a safe way to extract a column whose position is given by a variable. The multi-element operator pattern [, i] will not work out of the box in data.table, which expects [,i,with=F] instead, and the single-element operator pattern [[i]] will not work with matrices, which will return their ith element. Is there another operator that will extract safely a column over multiple classes of tables ? #Rstats