In , I always struggle to remember which is which between "type I" and "type II" errors (a.k.a. "alpha level" and "beta level"), because these names are so arbitrary. But I never fail to grasp the difference between "false positive" and "false negative", for the obvious reason that these terms are self-explanatory.

Wikipedia has a few words explaining why there is a difference between "type I error" and "false positive" despite being mathematically equal: en.wikipedia.org/wiki/False_po

3.8 was released today! Within it, the update of the CAGEr package (to analyse activity of gene promoters) brings a few bug fixes and new syntactic possibilities in the plotAnnot() function, using formula to express combinations of metadata. bioconductor.org/packages/3.8/

I am looking for a simple template system for producing or pages using input data serialised in simple tab-separated, files, or anything else that can be simply edited by non-programmers. The conversion would run through a git hook. Any suggestion ?

A new cap structure published by Munir, Banerjee and Shuman (Sloan-Kettering Institute, New York) in (academic.oup.com/nar/article/4). All is in the title: « NAD+-dependent synthesis of a 5′-phospho-ADP-ribosylated RNA/DNA cap by RNA 2′-phosphotransferase Tpt1 »

The Open Material Transfer Agreement Show more

First use of the technique in dioica, where double-strand breaks induce microdeletions when flanked by microhomology regions, because of the absence of the canonical non-homologous end-joining pathway. Deng, Henriet and Chourrout, 2018, Sars International Centre for Marine Molecular Biology, University of Bergen, Norway, linkinghub.elsevier.com/retrie

Journée Francophone de la Recherche à le 12 décembre 2018. Inscriptions : 1er novembre 2018 (contributions) / 03 décembre 2018 (auditeurs).

sciencescope.org/jfr-2018-jour

The best French-speaking symposium in Japan! Joke apart, it leverages the modest but significant size of our linguistic community to make a truly event.

With all due respect for the contribution of to , I would like to stop using "et al." in . (en.wikipedia.org/wiki/List_of_). This complicated way to say "and collaborators" is only a small obstacle for newcomers, but why keeping it in our digital age where a few extra characters will not cost precious ink and parchment anymore? I will probably go for "and coll." when not needing to follow an established style, unless there is a better alternative?

Xdrop: targeted sequencing of long DNA molecules from low input samples using droplet sorting. Show more

One step further towards entirely : Dou, collaborators and Baker published “De novo design of a fluorescence-activating β-barrel” in this week's issue of . Quoting their abstract: “This de novo design of small-molecule binding activity [...] should enable the design of increasingly sophisticated ligand-binding proteins, sensors and catalysts”. Meaning: computer-designing new enzymes instead of searching for them in natural diversity hotspots. doi.org/10.1038/s41586-018-050

The authors of the article “Oxygen regulation of breathing through an olfactory receptor activated by lactate” report in another article in Nature that they can not reproduce their main finding (a defect in the hypoxic ventilatory response of mutant of that olfactory receptor), which invalidates the “Oxygen regulation of breathing through an olfactory receptor” claim that makes most of their manuscript's title, but still they did not go as far as its . How come ?

Intrested in the Okinawa Institute of Science and Technology Graduate University () for a PhD or an internship ? There is a "OIST café" next week-end in . groups.oist.jp/grad/oist-cafe-

<Multi_key> <1> <1> <1> : "′" Show more

The edible ones are said to grow taller than 10 cm...

Earth Biogenome: an ambitious project to the of all living species on (actually, only eukaryotes; that excludes bacteria and archaebacteria, but includes unicellular organisms like yeast). Estimated data production in 10 years: 20 petabytes, well within the capacity of scientific infrastructures. earthbiogenome.org/

Distance to nuclear speckeles measured by quantitative sequencing shows stronger transcription deeper in nucleus. Show more

Using Debian packages on CentOS with the Environment Modules system Show more

Show more
Mastodon for Tech Folks

This Mastodon instance is for people interested in technology. Discussions aren't limited to technology, because tech folks shouldn't be limited to technology either!

We adhere to an adapted version of the TootCat Code of Conduct and follow the Toot Café list of blocked instances. Ash is the admin and is supported by Fuzzface as a moderator.

Hosting costs are largely covered by our generous supporters on Patreon – thanks for all the help!