Cells induced to differentiate and colonise a target organ: In this week's issue of #PNAS, by Han, ..., and Lerner from The Scripps, who found a single synthethic gene sending cells to the brain.
In brief: a library of single-chain antibodies was transfected in bone-marrow cells, which were translanted in mice. The cells that migrated in the brain were enriched for a synthethic gene expresing an #antibody that binds Vimentin and causes it to be phosphorylated. https://doi.org/10.1073/pnas.1719259115
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