Freezing cells using printing to encapsulate them in , which are then deposited on a glass slide cooled by liquid nitrogen: a recent article in by Akiyama, …, and Kanda: “Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing”, PNAS April 16, 2019 116 (16) 7738-7743; first published April 1, 2019

Astonished by the speed and quality of the testing company. They really made my day. The only thing they are clearly doing wrong is to be on Twitter instead of Mastodon.

More seriously, just make sure to use a disposable email address, etc., just in case, as their privacy policy mentions the possibility of collecting this data.

To everybody who writes a : please to not use tricks in your address; this is the best way to lose opportunities.

"Beyond disciplines", a report of the Japanese Science and Technology agency (JST)'s Center for Research and Development Strategy has just been translated in English. It outlines 12 themes, and is an important tool to understand 's scientific directions.

The first workshop in will be about and organised by my former colleagues from . 20 – 22 May 2019. More details at

I helped write a blog post explaining how Artsy hires engineers:

Engineering hiring is really broken, generally, and while our approach isn't perfect for every team, it's a source of strength for us.

Our manuscript describing the "C1 CAGE" method that we developed at to analyse gene expression () of single cells on the platform is finally published in Nature Communications ( The protocol itself has been already available for a couple of years directly on Fluidigm's website. Another method, not visible from the title, is also published in our manuscript: "color multiplexing" of single cells using live stains.

In “Programmable design of orthogonal heterodimers”, Chen, ..., and Baker (University of Washington and others) have calculated and produced entirely artificial protein domains that make exclusive (”orthogonal”) pairs. In comparison, our has only two pairs, A:T and C:G. This is another big breakthrough in biology Published this month in .

GitHub is now offering unlimited private repos for the "free" tier, s/th to keep in mind. My previously "academic" tier has apparenly been converted to "Pro".

I am very excited to see the R's %>% pipe operator becoming first class in thanks to the new plyrange package! See the paper of Lee, Cook and Lawrence (Genome Biology, 2019) for details.

Press implements a Data Availability section in its articles. In addition to ease access for the reader, it also helps the publisher to make the information machine-readable behind the scenes.

Just found, that will scan a PDF, DOCX or HTML-formatted document and tell if there are errors in the reported.

Sometimes I do not want to overwhelm or unfocus colleagues or collaborators with too many draft ideas at a time, but 15 years of professional experience have taught me that, in rare occasions, it is important to have a proof that I had a given idea independently, before somebody expressed it in a meeting. Thanks to the suggestion of our IT section, I am now exploring the use of ( or ( for that purpose.

TSS and RNA-seq data in a single experiment. Show more

A 3D-printed tongue mimic and many other things published in by researchers from the Institute of Technology.

Cats use hollow papillae to wick saliva into fur. Alexis C. Noel and David L. Hu. PNAS December 4, 2018 115 (49) 12377-12382

In , I always struggle to remember which is which between "type I" and "type II" errors (a.k.a. "alpha level" and "beta level"), because these names are so arbitrary. But I never fail to grasp the difference between "false positive" and "false negative", for the obvious reason that these terms are self-explanatory.

Wikipedia has a few words explaining why there is a difference between "type I error" and "false positive" despite being mathematically equal:

3.8 was released today! Within it, the update of the CAGEr package (to analyse activity of gene promoters) brings a few bug fixes and new syntactic possibilities in the plotAnnot() function, using formula to express combinations of metadata.

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Mastodon for Tech Folks

This Mastodon instance is for people interested in technology. Discussions aren't limited to technology, because tech folks shouldn't be limited to technology either!

We adhere to an adapted version of the TootCat Code of Conduct and follow the Toot Café list of blocked instances. Ash is the admin and is supported by Fuzzface, Brian!, and Daniel Glus as moderators.

Hosting costs are largely covered by our generous supporters on Patreon – thanks for all the help!