The Do’s & Don’ts of Hyperlinks in Grant Applications Show more

We are a in the research unit where I am working, at the Okinawa Institute of Science and Technology Graduate University (). We are studying the genetic variations of a small animal called dioica. Its exceptionally compact (70 Mbp) may help us understand how to design a genome from scratch. OIST is an incredible place, diverse, pluridisciplinary and , inserted in a fantastic natural environment. oist.jp/careers/postdoctoral-r

A single-chain was developed to bind and stabilise (histone proteins with wrapped on) by Zhou, collaborators and Zhang (Nature Communications, nature.com/articles/s41467-019). This allowed them make beautiful images of centromeric nucleosomes by cryo-electronic . (Screenshot from the paper licensed CC-BY 4.0)

I just discovered with horror in that the industrialised agriculture that produces oil kills millions of birds per year. nature.com/articles/d41586-019

After 9 months at the Okinawa Institute of Science and Technology, I still find a sense of pride every time I start my day walking though its impressive tunnel gallery. OIST is growing and will soon reach a thousand employees. Still, it may have been a surprise to some that a labour was formed. From my point of view, this is consubstantial with growth. One of the union's founders had his contract not renewed. Please join me in supporting him by asking OIST to reinstate him. t.co/Ppm38utPVE

The 13th International Workshop on Advanced () taking place in in June 25th~27th (this year 2019) has an interesting program covering genomic medicine, genome regulation, cancer genomics, chromatin structure, single cells, new technologies and genome editing. Don't be scared by the news message in Japanese on the front page, the whole meeting is in English. gt164.jpn.org/13agw/

Freezing cells using printing to encapsulate them in , which are then deposited on a glass slide cooled by liquid nitrogen: a recent article in by Akiyama, …, and Kanda: “Cryoprotectant-free cryopreservation of mammalian cells by superflash freezing”, PNAS April 16, 2019 116 (16) 7738-7743; first published April 1, 2019 doi.org/10.1073/pnas.180864511

Astonished by the speed and quality of the testing company. They really made my day. The only thing they are clearly doing wrong is to be on Twitter instead of Mastodon.

dnafriend.com/

More seriously, just make sure to use a disposable email address, etc., just in case, as their privacy policy mentions the possibility of collecting this data.

To everybody who writes a : please to not use tricks in your address; this is the best way to lose opportunities.

"Beyond disciplines", a report of the Japanese Science and Technology agency (JST)'s Center for Research and Development Strategy has just been translated in English. It outlines 12 themes, and is an important tool to understand 's scientific directions. jst.go.jp/crds/en/publications

The first workshop in will be about and organised by my former colleagues from . 20 – 22 May 2019. More details at meetings.embo.org/event/19-sin

I helped write a blog post explaining how Artsy hires engineers: artsy.github.io/blog/2019/01/2

Engineering hiring is really broken, generally, and while our approach isn't perfect for every team, it's a source of strength for us.

Our manuscript describing the "C1 CAGE" method that we developed at to analyse gene expression () of single cells on the platform is finally published in Nature Communications (nature.com/articles/s41467-018). The protocol itself has been already available for a couple of years directly on Fluidigm's website. Another method, not visible from the title, is also published in our manuscript: "color multiplexing" of single cells using live stains.

In “Programmable design of orthogonal heterodimers”, Chen, ..., and Baker (University of Washington and others) have calculated and produced entirely artificial protein domains that make exclusive (”orthogonal”) pairs. In comparison, our has only two pairs, A:T and C:G. This is another big breakthrough in biology Published this month in . doi.org/10.1038/s41586-018-080

GitHub is now offering unlimited private repos for the "free" tier, s/th to keep in mind. My previously "academic" tier has apparenly been converted to "Pro".
blog.github.com/2019-01-07-new

I am very excited to see the R's %>% pipe operator becoming first class in thanks to the new plyrange package! See the paper of Lee, Cook and Lawrence (Genome Biology, 2019) for details. genomebiology.biomedcentral.co

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Mastodon for Tech Folks

This Mastodon instance is for people interested in technology. Discussions aren't limited to technology, because tech folks shouldn't be limited to technology either! We adhere to an adapted version of the TootCat Code of Conduct and follow the Toot Café list of blocked instances. Ash is the admin and is supported by Fuzzface, Brian!, and Daniel Glus as moderators. Hosting costs are largely covered by our generous supporters on Patreon – thanks for all the help!